The 7 Most Effective Antivirus Programs of 2022 Best Overall: Bitdefender Antivirus Plus. Norton 360 with LifeLock is the best option for Windows. Webroot SecureAnywhere for Mac is the best option for Mac users. McAfee Antivirus Plus is the best option for protecting multiple devices. I recommend Trend Micro Antivirus+ Security as the best premium option. Malwarebytes offers the most effective scanning for malware.